CSL Ltd Annual Report 2020

Dear Stakeholders, In writing this message we have had the opportunity to reflect on the sobering and far-reaching impact that the COVID-19 pandemic has had on our global community. While the pandemic has certainly added complexity to our business and operating environment, CSL has had a number of notable achievements throughout the year, including the Company’s 25th anniversary as a listed company on the Australian Securities Exchange. We are pleased to share some of those success stories in this report. Business Highlights CSL has continued to deliver value to shareholders because of our unwavering focus on delivering innovative products to people with rare and serious disease, and to protecting the health of the public with our influenza vaccines portfolio. This year we made a series of investments designed to strengthen the next-generation therapeutic areas within our portfolio. We exercised an option to fully acquire biotechnology company Vitaeris, specifically its late-stage monoclonal antibody therapy to address long-term rejection in kidney transplants. Additionally, subject to receiving regulatory approval we acquired the exclusive global license rights to commercialise a Phase 3 stage programadeno-associated virus (AAV) gene therapy program for the treatment of haemophilia B from uniQure, an asset that if successful will prove transformational for patients suffering this disease. Expanding our stem cell gene therapy portfolio, we established an alliance with Seattle Children’s Research Institute to develop stem cell gene therapies for primary immunodeficiency diseases. We also entered into a long-term strategic partnership with Thermo Fisher Scientific for the lease of our state-of-the-art biotech manufacturing facility currently under construction in Lengnau, Switzerland. When construction is complete, Thermo Fisher will lease and operate the Lengnau facility and provide production support for CSL’s biologics portfolio. This decision was made following a strategic review and will allow us to access capabilities from an experienced partner and leverage our own internal investments. While some clinical trial stage programs in our research portfolio have been slowed due to COVID-19, our Phase 3 program investigating CSL112 for reduction of recurrent cardiovascular events is progressing well. Over 9,500 patients are now recruited and the results of a futility analysis have provided us the confidence to continue as planned. As we’ve seen with the recent registration of Flucelvax in Europe, Seqirus continues to go from strength to strength as its differentiated product portfolio gains a strong reputation in global markets. Our relationships with the biomedical community have always been critical to the way we approach our innovation portfolio. In planning for future growth, we made the decision to build a bespoke facility to house our Company’s Australian headquarters and expand our R&D footprint with a new 16-storey building in the heart of Melbourne’s biomedical precinct. It will accommodate 800 employees from 2024. The move ensures we are well placed to strengthen our partnerships and deepen the valuable relationships we have with the local biomedical community. The move will also bring key elements of our Australian operations together, fostering stronger internal collaboration. With our robust research and development (R&D) pipeline, Commercial and Operations excellence, passionate people and global reputation as a leading biotechnology company, we have delivered a strong result for the year. It reflects the focused execution of our strategy, robust demand for our differentiated medicines and our commitment for meeting the needs of people who rely on our therapies. We are pleased to deliver a record dividend to shareholders of US$2.02 per share for 2020. US$2,103 million in reported net profit after tax. US$2.02 dividend per share for 2020. CSL Limited Annual Report 2020 2 Chairman and CEO Message 1