CSL Ltd Annual Report 2020

Therapeutic Areas Platform Plasma Fractionation Immunology Haematology Respiratory Cardiovascular and Metabolic Influenza Vaccines (Seasonal, Pandemic) Transplant Recombinant Technology Cell and Gene Therapy Cell-based Adjuvanted Egg-based Innovation and collaboration are the engine that drives CSL. We invest in research and development (R&D), enabling our continued growth. Expanding our R&D footprint CSL continues to build an integrated, global R&D organisation that assembles coordinated international project teams, drawing together talented staff from different countries to collaborate with each other and with medical research institutions everywhere to advance our programs. With more than 1,700 scientists in nine countries, a global leadership team situated around the world and important R&D centres in Melbourne, Australia; Bern, Switzerland; Marburg, Germany; Pasadena, California, US; and King of Prussia, Pennsylvania, US, we have access to worldwide, leading innovation from within and outside CSL. In the past year, CSL has strategically grown its footprint and alliances in close proximity to its R&D centres to help foster and access external innovation while also continuing to evolve internally. In this way, we can continually deliver meaningful benefit to patients while growing in a fiscally responsible way. The following are some notable examples of our strategic growth. – Breaking ground on CSL’s new global headquarters in the Parkville Biomedical Precinct in Melbourne, Australia. Scheduled for completion in 2024, the facility will house around 800 employees including early stage research and product development teams and include leading-edge laboratories along with space for external collaborators and start-ups. – Construction of CSL Behring’s R&D campus in Marburg, Germany. Scheduled for completion in 2022, the R&D campus will accommodate around 600 staff, house state-of-the-art laboratories and create opportunity for external partners and collaborators to work with us. – Expanding CSL Behring’s R&D facility in Pasadena, California, US. This will enable us to focus on cell and gene therapy that promises to advance our new capabilities in this scientific platform. The Pasadena location allows for strategic collaboration both in the cell and gene therapy arena but also gives CSL a strategic presence along the west coast of the US. – Opening CSL Behring’s first laboratory in Philadelphia, a short drive from its US headquarters in King of Prussia, Pennsylvania. Located at the University City Science Center, steps fromworld-class research institutions and universities, this CSL R&D laboratory will bring together bright scientific minds from CSL sites around the world to maximise our ability to uncover disruptive scientific methods that could help ensure patients with rare or serious diseases have the medicines they need in the future. CSL also continues to partner with the University City Science Center to fund promising research through the CSL’s Research Acceleration Initiative, which offers grants to researchers around the globe working in CSL’s scientific areas of interest. – Officially opening the Swiss Institute for Translational and Entrepreneurial Medicine – known as sitem-insel – in 2019, on the campus of the University of Bern hospital. This unique facility provides the infrastructure to cultivate research findings or prototypes to marketable products and uniquely houses an established biotechnology company along with academic researchers and start-up biotechnology companies. CSL’s Biologics Research Centre will be situated at sitem-insel. CSL will be the sole large biotechnology company on-site and we will conduct our own research and enter into meaningful collaborations with scientists from both the academic and start-up arenas. Investment in our R&D pipeline In 2019/20, CSL invested US$922 million* in R&D across our businesses with a focus on our six therapeutic areas – immunology, haematology, cardiovascular and metabolic, respiratory, transplant, and influenza – and four scientific platforms – plasma fractionation, recombinant protein technology, cell and gene therapy, and cell-based and egg-based vaccines. In addition, CSL continues to build on its capabilities across the R&D value chain, from discovery research to pharmacovigilance to its currently marketed therapies. Such proficiency is critical as R&D builds the novel and diverse pipeline of the future. For a detailed view of our diverse and balanced product pipeline see page 11 of this report. CSL continues to look for strategic collaborations and acquisitions that align with our therapeutic areas of focus. * Limited assurance by Ernst & Young. CSL Limited Annual Report 2020 21 7 Powered by Innovation